AO2 MIST

OXYGEN SKINCARE FOR HYDRATION & BALANCE

SKU: HYD-Sample Category:
INTRODUCING AO2 MIST

A DAILY OXYGEN REFRESH FOR YOUR SKIN.

AO2 MIST

AO2 MIST is a lightweight face + body mist that instantly refreshes and revitalizes skin throughout the day.

Built on the same oxygen nanobubble technology as AO2 CLEAR and AO2 HYDRATE.MIST delivers a clean, breathable refresh in a fine, fast-drying spray with no residue or heaviness. It doesn’t replace your CLEAR or HYDRATE routine… It’s what you reach for in between.

BENEFITS
  • Refreshes tired-looking skin instantly
  • Delivers a clean, cooling sensory reset experience
  • Provides lightweight hydration support — no heaviness or residue
  • Helps skin feel softer, calmer, and more refreshed
  • Supports face + body use, all day long
Where It Fits in Your Routine

MIST is additive, not a replacement. Use it on top of — not instead of — your AO2 CLEAR or HYDRATE routine, your moisturizer, sunscreen, or makeup. Think of it as the step you add whenever skin needs an instant reset, not a step you swap in.

When to Use It

AO2 MIST is meant to be your portable skin refresher. Use it any time, anywhere, to keep your skin revitalized and protected against the elements. 

    • Morning routine
    • Post-workout
    • Mid-day refresh
    • Travel / airplanes
    • Post-sun exposure
    • After showering
    • Dry climates or air-conditioned environments
    • Anytime skin feels dry, fatigued, or overheated
Ingredients

Distilled water

A clean, minimal base — consistent with AO2’s fewer-ingredients philosophy.

Oxygen nanobubbles

AO2’s core nanobubble technology stabilizes extremely small oxygen-filled bubbles in water, letting the mist interact closely with the skin’s surface for a clean, breathable, revitalizing feel.

<1% preservative (PhE)

The minimum needed to keep the formula stable — nothing more.

How to Use It
  1. Spray lightly over face or body
  2. 2–5 sprays per use
  3. Allow to absorb naturally
  4. Reapply throughout the day as needed

Compatible with: AO2 CLEAR / HYDRATE, moisturizers, sunscreen, makeup, and post-procedure regimens.

Why You'll Love It
  • Ultra-fine cooling mist
  • Skin feels refreshed, calm, softer, more hydrated
  • Feels awake and revitalized — not weighed down
  • Fits any moment of the day, face or body

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Shipping is currently available to the US, Canada, Europe and Australia! If you don’t see your country, please get in touch with us. 

Why YOU’LL LOVE AO2 MIST

A superfine spray that disperses oxygen nanobubbles evenly across skin
Designed for any skin type, reapplied as often as skin needs it
Delivers a refresh without heaviness, with just three simple, clean ingredients
powered by our patented oxygen nanobubble technology

Oxygen + SPRAY: A Synergistic Duo

AO2 MIST delivers hundreds of millions of oxygen nanobubbles in distilled water through a superfine spray — and the spray itself is part of the science, not just the format. When a fine water mist fragments on contact with skin, it generates a natural electrical effect at the droplet surface, known as spray electrification (or the Lenard effect).

Early research on the negative air ions this creates points to positive skin benefits, supporting the skin’s natural defenses against everyday environmental stress, among others. Paired with AO2’s oxygen nanobubbles, MIST’s spray delivery is designed to work with skin’s own chemistry, not just sit on top of it.

AO2 MIST Daily oxygen nanobubble skin therapy
A02 Clear Results in just 8 Weeks

A REFRESH You Can Feel

A02 Clear Results in just 8 Weeks

Daily life is full of stressors that quietly lower your skin’s oxygen tension — wind, smoke, dust, recirculated air, blue light, extreme heat. Left unchecked, that shows up as dull, tired-looking skin. AO2 MIST replenishes oxygen exposure at the surface throughout the day, whatever your skin is up against.

  • Refreshes and revives — a cooling burst that reawakens tired, travel-worn, or overheated skin

  • Calms and soothes — a gentle, fine mist designed to feel comfortable on sensitive or reactive skin

  • Replenishes oxygen exposure — tops up skin’s contact with oxygen nanobubbles throughout the day

  • Boosts absorption — preps skin so serum, moisturizer, and SPF layer on smoothly right after

  • Leaves no residue — fast-drying and light enough to wear under makeup

A Refresh You Can Feel

Daily life is full of stressors that quietly lower your skin’s oxygen tension — wind, smoke, dust, recirculated air, blue light, extreme heat. Left unchecked, that shows up as dull, tired-looking skin. AO2 MIST replenishes oxygen exposure at the surface throughout the day, whatever your skin is up against.

  • Refreshes and revives — a cooling burst that reawakens tired, travel-worn, or overheated skin

  • Calms and soothes — a gentle, fine mist designed to feel comfortable on sensitive or reactive skin

  • Replenishes oxygen exposure — tops up skin’s contact with oxygen nanobubbles throughout the day

  • Boosts absorption — preps skin so serum, moisturizer, and SPF layer on smoothly right after

  • Leaves no residue — fast-drying and light enough to wear under makeup

“An ultra-light, fast-absorbing refresh I reached for during my weekly routine, at my desk, after workouts, and while traveling“

EASILY FITS INTO YOUR EXISTING ROUTINE

Step 1: Anytime, anywhere
No prep needed. AO2 MIST works any moment your skin needs a reset, with or without a routine first.

Step 2: Spray
Hold 2–3 inches from skin and mist 5–10 sprays over face or body. More sprays equals more oxygen.

Step 3: Apply to Skin
Apply the solution generously to your entire face using gentle, circular motions. If your skin is sensitive or you have an active breakout, lightly dab instead of scrubbing.

Step 4: Let It Absorb
Allow your skin to air dry naturally. Do NOT wipe off.

Step 5: Continue with Your Routine
Apply your serum, moisturizer, or SPF while your skin is still slightly damp to lock in the refresh.

Pro Tip:
Keep MIST in your bag, car, or desk drawer for instant reapplication whenever your skin feels dull, dry, or overheated.

Makeup Tip:
Customers who apply AO2 MIST over their makeup report that it holds it in place.

A02 Clear Results in just 8 Weeks

EASILY FITS INTO YOUR ROUTINE

Step 1: Anytime, anywhere

No prep needed. AO2 MIST works any moment your skin needs a reset, with or without a routine first.

Step 2: Spray
Hold 2–3 inches from skin and mist 5–10 sprays over face or body. More sprays equals more oxygen.

Step 3: Apply to Skin
Apply the solution generously to your entire face using gentle, circular motions. If your skin is sensitive or you have an active breakout, lightly dab instead of scrubbing.

Step 4: Let It Absorb
Allow your skin to air dry naturally. Do NOT wipe off.

Step 5: Continue with Your Routine
Apply your serum, moisturizer, or SPF while your skin is still slightly damp to lock in the refresh.

Pro Tip:
Keep MIST in your bag, car, or desk drawer for instant reapplication whenever your skin feels dull, dry, or overheated.

Makeup Tip:
Customers who apply AO2 MIST over their makeup report that it holds it in place.

WHICH AO2 SKIN PRODUCT IS RIGHT FOR YOU

CLINICAL RESEARCH

Evidence of Oxygen Delivery Beneath the Skin Surface Without Disrupting the Skin Barrier

Researchers examined what happens inside human skin after topical application of AO2 SKIN's oxygen nanobubbles, including oxygen penetration and skin barrier integrity

SEE FULL STUDY INCLUDING VIDEO AND DETAILED RESULTS 

THE STUDY

The First-of-Its-Kind Human Oxygen Nanobubble Enzyme Study

Conducted in collaboration with North Carolina State University and a board-certified dermatologist and nano-physicist, this study examined human skin biopsies collected before treatment and at 30- and 60-minute intervals following topical application of AO2 SKIN oxygen nanobubbles.

  • Human skin biopsies collected and analyzed directly
  • Quantitative immunofluorescence imaging
  • Independent academic research collaboration
  • Evaluation of oxygen-related biomarkers and skin barrier integrity

HOW OXYGEN WAS MEASURED

Your Skin Has It's Own Oxygen Sensor

Your skin naturally has different oxygen levels at different depths. One important marker, called Hypoxia Inducible Factor-1 alpha (HIF-1α), helps scientists understand how much oxygen is available in the skin. When oxygen levels increase, this marker goes down.
 
AO2 CLEAR® oxygen nanobubbles were applied to the skin, and biopsies were collected before treatment and again at 30 and 60 minutes following application.

FINDING 01

Oxygen Actually Reaches The Epidermis and Dermis

The study measured HIF-1α, a biomarker that rises when skin is low on oxygen and drops when oxygen improves. After applying AO2 SKIN, HIF-1α decreased significantly; direct biochemical proof that oxygen was delivered into the tissue.
 
  • HIF-1α is a validated scientific measure of tissue oxygenation
  • Results were significant at both 30 and 60 minutes
  • This is the body's own oxygen sensor confirming the positive penetration and effects of AO2

FINDING 02

Your Skin's Own Defenses Get Stronger

Beyond oxygenation, the study found that AO2 SKIN activates the skin's natural antioxidant defense system. Two key protective enzymes, NQO1 and HO-1, increased significantly, and HO-1 kept rising through 60 minutes, suggesting a lasting protective effect.
 
  • NQO1 elevated at 30 minutes — fast activation
  • HO-1 continued rising through 60 minutes — sustained defense
  • AO2 gives the skin a very strong defense after treatment.
  • Skin becomes more resilient to environmental stressors

FINDING 03

Your Skin Barrier Stays Completely Intact

Filaggrin, the key protein responsible for your skin's barrier function and hydration, showed zero change across all time points. The treatment delivers oxygen without disrupting the skin's protective layer.
 
  • Filaggrin levels unchanged at T0, T30, and T60
  • No disruption to the stratum corneum structure
  • Safe and non-disruptive — confirmed at the cellular level

WHAT THIS MEANS FOR YOUR SKIN

Targeted Oxygen Delivery. Stronger Skin. No Disruption.

  • Supports better oxygen availability at the pore and follicle level
  • Helps create a healthier environment for skin function
  • Maintains skin barrier integrity
  • Encourages a more balanced, resilient complexion
This research supports how oxygen nanobubble technology from AO2 SKIN works to improve overall skin health in a gentle, non-disruptive way.

STUDY ARCHITECTS

Dr. Zvi Yaniv, PhD

Dr. Zvi Yaniv, PhD

Chief Science Officer, AO2 SKIN

Nanotechnology pioneer with over 300 patents. The scientific architect behind AO2 SKIN's oxygen nanobubble delivery technology.

Vivian Bucay, MD, FAAD

Vivian Bucay, MD, FAAD

Chief Medical Officer, AO2 SKIN

Johns Hopkins and Baylor College of Medicine graduate. Considered one of the pre-eminent dermatologists in the United States.

Giuseppe Valacchi, PhD

Giuseppe Valacchi, PhD

David H. Murdock Distinguished Professor of Regenerative Medicine

World-leading expert in redox biology and skin science. Holds NC State's highest faculty distinction.

MIST FAQs

Should I use MIST, CLEAR or HYDRATE?
  • AO2 MIST → Sensitive/Normal/combination skin, perfect for anytime, anywhere to keep your skin oxygenated.
  • AO2 CLEAR → Normal/combination skin, layering with other actives, post-procedure protocols where “less is more.”
  • AO2 HYDRATE → Dry or mature skin, urban environments, frequent travel, post-procedure when skin needs extra comfort.
  • Many people use CLEAR in the morning (lightweight), MIST throughout the day (on the go), and HYDRATE at night (extra barrier support).
Is AO2 HYDRATE safe for everyone?

Yes. AO2 HYDRATE is completely safe for all people and all skin types. It’s even safe to use while pregnant, nursing or trying to conceive. Our ingredient list is short:

  1. Distilled water
  2. Billions of oxygen nanobubbles
  3. Natural vegatable glyercin

 

What results can I expect to see on my skin?

With consistent use your skin should be clearer, more hydrated, evenly textured, brighter, and overall healthier and better nourished. You should not experience the drying or irritation that accompanies many traditional acne products like Retin-A.

How do I use AO2 HYDRATE?

Apply twice daily after you wash and dry your face using the following steps:

1. Place a fresh new sponge in the tray (Do not reuse sponges—used sponges can collect and breed bacteria)

2. Dispense AO2 HYDRATE solution onto the sponge until fully saturated (a drippy sponge delivers the best results)

3. Apply liberally to your entire face—for sensitive skin or active breakouts, dab the product onto your skin rather than scrubbing to avoid potential irritation

4. Let your skin air dry until it’s almost dry, then apply your next product while it’s still slightly damp—do not pat dry

5. Apply any additional products from your existing skincare routine, such as moisturizer or sunscreen

NOTE: Be consistent to get maximum results. Each pouch contains 15 applications and is meant to be used twice a day. Discard each pouch 14 days after opening—even if there’s liquid left, switching to a fresh pouch ensures you’re getting the most effective product.

Do I have to give up my existing skin care routine to use AO2 HYDRATE?

Nope! Because AO2 HYDRATE is a unique and hyper clean product it fits right into your existing routine, whether that’s cleanse and go a multi-step regimen.

Remember to be consistent and use it twice daily after washing and drying your face. Then, once you apply your AO2 HYDRATE, let it air dry. If you wipe your face, you are wiping off the oxygen. 

What side effects are associated with AO2 HYDRATE?

Because AO2 HYDRATE is made with only oxygen, distilled water, and natural vegetable glycerinthere is no potential for irritation or other adverse reactions.

Can I reuse sponges? What about the tray?

NO! We recommend you use a fresh new sponge with each application. A previously used sponge can harbor bacteria (either removed from your skin during the AO2 application or aerosolized in the bathroom). If you reuse the same sponge later you are risking adding bacteria back to your skin surface.

Your sponge is also compostable so you don’t need to worry about filling up the landfill.  Toss them in your compost or the trash as they will biodegrade.

For the tray, you can reuse it. We recommend you wash the trays with soap and water and store them in a drawer or cabinet. Because they are not as porous as the sponges, a quick clean between uses will minimize any bacterial growth.

How long before I see results?

If using AO2 HYDRATE consistently twice daily, you should start to see improvement within 2 to 4 weeks. Because oxygen acts as a natural antibacterial against the specific bacteria that causes acne inflammation the preventative benefits act cumulatively—the longer you use the product, the more benefit you can expect to see—clarity, hydration, and even texture.

Can I use other acne treatments while using AO2 HYDRATE?

Because AO2 HYDRATE’s hyper clean formula consists of just distilled water,  oxygen nanobubbles and natural vegetable glycerin that clear and hydrate your skin you can use it in conjunction with other treatments. Many of our study participants and customers found that while AO2 HYDRATE  and AO2 CLEAR their next product in their regimen worked even better.

For advice on any prescription medication changes, please contact your medical or healthcare provider.

Can men use AO2 CLEAR and HYDRATE?

Absolutely. Both products are gender-neutral, fast-absorbing, and leave no residue. Many men like Clear as a post-shave soothing step, and Hydrate as a simple all-in-one moisturizer.

Do you recommend any different usage based on skin type or acne severity?

We find that people with sensitive skin or severe or very inflamed acne should apply using light pressure so as not to irritate your skin with the sponge texture. Those who don’t have sensitive skin and/or have a lot of blackheads and whiteheads can press more firmly for more exfoliation. For your personal medical concerns please seek the advice of your medical or healthcare provider.

How often should I use AO2 HYDRATE?

Use AO2 HYDRATE twice daily, once in the morning and once at night, on clean, dry skin. It should be the first step after cleansing and before applying serums, moisturizers, or SPF. AO2 HYDRATE easily fits into any skincare routine without requiring you to change anything else.

Each 30-day kit comes with four pouches, and each pouch contains 15 applications (used twice a day). Once opened, a pouch is most effective when used within 14 days, so we recommend replacing the cap tightly after each use to keep the oxygen nanobubbles potent.

With consistent daily use, most people start to see real improvements in 2 to 4 weeks—think clearer, calmer, and more hydrated skin.

How is AO2 HYDRATE different from other products that deliver oxygen to the skin?

AO2 HYDRATE uses patented nanobubble oxygen technology. Unlike creams, foams, or masks that make “oxygen” claims without proven delivery, our nanobubbles are 1,000× smaller than pores and stay stable in water. This allows oxygen to reach deep into the skin’s micro-environment. Hydrate adds 5% vegetable glycerin for long-lasting hydration, so you get both oxygen delivery and barrier-support.

Do I have to use the provided sponges for application?

The sponges are sized to hold the correct amount of AO2 Clear for each application making it easy to administer an equal amount twice daily for two weeks. 

The sponges have also been designed to give you gentle exfoliation that can help clear your pores of dead skin cells and make way for our oxygen nanobubbles to get to work. If you notice any persistent redness or irritation it is likely that your skin needs less exfoliation and we recommend switching to a cotton round or fine gauze instead.

What is the shelf life of AO2 HYDRATE?

AO2 HYDRATE has a shelf life of 1 year if unopened and stored in a cool place. You will see the manufacturing date of your A02 on the back of each pouch on the bottom.

Once you open your A02 HYDRATE pouch, it has a maximum efficacy of 14 days. It can be stored in your bathroom or the refrigerator depending on your preference.

Each pouch contains 15 applications. We recommend you use AO2 HYDRATE twice daily for 3o consecutive days for maximum benefit.  Also remember to use a fresh clean sponge with each applications.

Where do you ship?

We currently ship to the United States, Canada, United Kingdom, Ireland, France, Germany, most of Western Europe and Australia. If your country isn’t listed, we’re constantly exploring opportunities to expand our reach! Stay tuned for updates or contact our support team for more information.  Just reach out to info@ao2clear.

What if I forget to put the cap back on the pouch?

Closing the cap quickly and tightly is a critical step in ensuring maximum product effectiveness for the duration of each two week pouch. If left open the nanobubbles will begin to rise to the surface and pop, decreasing oxygen concentration in the solution. Without a high oxygen concentration AO2 HYDRATE will not work as well, so please close quickly and tightly. 

Fair questions. Straight answers.

Is AO2 MIST safe for everyone?

Yes. AO2 MIST is completely safe for all people and all skin types. It’s even safe to use while pregnant, nursing or trying to conceive.

Should I use MIST, CLEAR or HYDRATE?
  • AO2 MIST → Sensitive/Normal/combination skin, perfect for anytime, anywhere to keep your skin oxygenated.
  • AO2 CLEAR → Normal/combination skin, layering with other actives, post-procedure protocols where “less is more.”
  • AO2 HYDRATE → Dry or mature skin, urban environments, frequent travel, post-procedure when skin needs extra comfort.
  • Many people use CLEAR in the morning (lightweight), MIST throughout the day (on the go), and HYDRATE at night (extra barrier support).
What results can I expect to see on my skin?
With consistent use your skin should be clearer, more hydrated, evenly textured, brighter, and overall healthier and better nourished. You should not experience the drying or irritation that accompanies many traditional acne products like Retin-A.
What side effects are associated with AO2 CLEAR?
Because AO2 CLEAR is made with only oxygen and distilled water, there is no potential for irritation or other adverse reactions with either product.
How often should I use AO2 CLEAR?
We recommend using AO2 CLEAR twice daily after washing and drying your face with a mild cleanser. Each pouch is measured to provide 15 applications, twice daily for a week.
How long before I see results?
If using AO2 CLEAR consistently twice daily, you should start to see improvement within the first two weeks. Because oxygen acts as a natural antibacterial against the specific bacteria that causes acne inflammation the preventative benefits act cumulatively. The longer you use the product, the more benefit you can expect to see clarity, hydration, and even texture.
Do I have to give up my existing skin care routine to use AO2 CLEAR?
Nope! Because both AO2 CLEAR is a unique and hyper clean product they fit right into your existing routine, whether that’s cleanse and go a multi-step regimen. Start with your favorite cleanser, then apply AO2 CLEAR,  and allow the solution to air dry. Make sure your sponge is fully saturated and drippy, it will dry quickly and your face won’t be wet long. After that you can apply whatever creams or serums you like.
Can I use other acne treatments while using AO2 CLEAR?
Because AO2 CLEAR’s hyper clean formula consists of just distilled water and oxygen nanobubbles that clear and hydrate your skin you can use it in conjunction with other treatments. But, many of our study participants and customers found it unnecessary to continue their other treatments because of how effective and gentle AO2 CLEAR is on their skin. For advice on any prescription medication changes, please contact your medical or healthcare provider.
Do you recommend any different usage based on skin type or acne severity?
We find that people with sensitive skin or severe or very inflamed acne should apply using light pressure so as not to irritate your skin with the sponge texture. Those who don’t have sensitive skin and/or have a lot of blackheads and whiteheads can press more firmly for more exfoliation. For your personal medical concerns please seek the advice of your medical or healthcare provider.
How is AO2 CLEAR different from other products that deliver oxygen to the skin?
AO2 CLEAR is the only product to harness nanobubble technology for such an extraordinarily high gradient of oxygen pressure. No other product is as clean and powerful.
How exactly does the nanobubble gradient work?
The transfer of a gas like oxygen from one location to another depends on the difference, or gradient, in concentration between the two locations. If that gradient is significant, oxygen will move from the high-concentration one to the low-concentration one. In our case, the two locations are the skin surface and the skin pores. A good example of an oxygen gradient is hyperbaric oxygen therapy. This treatment is costly, cumbersome, and has the potential for serious side effects. AO2 uses the same principle of an oxygen gradient as hyperbaric therapy, but it’s convenient, low cost, and has no potential side effects.
How do we know what is better between oxygen, hydrogen or ozone?
Oxygen is critical in promoting healthy skin by supporting cell regeneration and collagen production. It helps enhance skin elasticity, reduce the appearance of fine lines and wrinkles, and contributes to a radiant complexion. Additionally, oxygen can assist in healing wounds and combating bacteria, promoting an overall rejuvenated and refreshed skin appearance.

Hydrogen, although it has some antioxidant properties, doesn’t play as central a role in these essential functions for skin. While ozone has some antioxidant and antimicrobial benefits, its use in skincare is debated due to concerns about potential side effects and limited scientific evidence. Oxygen is generally considered safer and more widely accepted for skincare, offering proven advantages without the uncertainties associated with hydrogen and ozone.

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