Clear Starts with Oxygen

AO2 SKIN™ is revolutionizing skincare with patented nanobubble delivery technology. Our products use nanobubbles 1/1000th the size of a pore to deliver beneficial gases deep into the skin, providing all skin types with radically clean, simple yet effective solutions without harsh chemicals or long ingredient lists.

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What Makes AO2 SKIN Different?

More Oxygen. Stronger Skin. No Disruption.

Most skincare products rely on long ingredient lists, harsh actives, or complicated routines.
AO2 SKIN™ takes a radically different approach.
Using only distilled water and oxygen nanobubbles, AO2 SKIN helps increase oxygen availability within the skin while maintaining skin barrier integrity.

Independent research conducted with North Carolina State University demonstrated measurable changes in oxygen-related biomarkers following topical application of AO2 CLEAR® oxygen nanobubbles.
Simple ingredients. Measurable science.

HOW TO USE AO2

What Makes AO2 SKIN Different?

More Oxygen. Stronger Skin. No Disruption.
Most skincare products rely on long ingredient lists, harsh actives, or complicated routines.
AO2 SKIN™ takes a radically different approach. Using only distilled water and oxygen nanobubbles, AO2 SKIN helps increase oxygen availability within the skin while maintaining skin barrier integrity.

Independent research conducted with North Carolina State University demonstrated measurable changes in oxygen-related biomarkers following topical application of AO2 CLEAR® oxygen nanobubbles.

HOW TO USE AO2

AO2 SKIN Oxygen Nanobubble killing acne causing bacteria

WHAT ARE GAS NANOBUBBLES?

Tiny Bubbles. Big Difference.
Nanobubbles are microscopic pockets of oxygen suspended in water.
Unlike ordinary bubbles that quickly rise and disappear, nanobubbles remain stable in solution, allowing billions of oxygen nanobubbles to interact with the skin in ways traditional bubbles cannot.

THE SCIENCE

CLINICAL RESEARCH

Evidence of Oxygen Delivery Beneath the Skin Surface Without Disrupting the Skin Barrier

Researchers examined what happens inside human skin after topical application of AO2 SKIN’s oxygen nanobubbles, including oxygen penetration and skin barrier integrity

SEE FULL STUDY INCLUDING VIDEO AND DETAILED RESULTS

THE STUDY

The First-of-Its-Kind Human Oxygen Nanobubble Enzyme Study

Conducted in collaboration with North Carolina State University and a board-certified dermatologist and nano-physicist, this study examined human skin biopsies collected before treatment and at 30- and 60-minute intervals following topical application of AO2 SKIN oxygen nanobubbles.

Human skin biopsies collected and analyzed directly
Quantitative immunofluorescence imaging
Independent academic research collaboration
Evaluation of oxygen-related biomarkers and skin barrier integrity

HOW OXYGEN WAS MEASURED

Your Skin Has It’s Own Oxygen Sensor

Your skin naturally has different oxygen levels at different depths. One important marker, called Hypoxia Inducible Factor-1 alpha (HIF-1α), helps scientists understand how much oxygen is available in the skin. When oxygen levels increase, this marker goes down.

AO2 CLEAR® oxygen nanobubbles were applied to the skin, and biopsies were collected before treatment and again at 30 and 60 minutes following application.

FINDING 01

Oxygen Actually Reaches The Epidermis and Dermis

The study measured HIF-1α, a biomarker that rises when skin is low on oxygen and drops when oxygen improves. After applying AO2 SKIN, HIF-1α decreased significantly; direct biochemical proof that oxygen was delivered into the tissue.

HIF-1α is a validated scientific measure of tissue oxygenation
Results were significant at both 30 and 60 minutes
This is the body’s own oxygen sensor confirming the positive penetration and effects of AO2

FINDING 02

Your Skin’s Own Defenses Get Stronger

Beyond oxygenation, the study found that AO2 SKIN activates the skin’s natural antioxidant defense system. Two key protective enzymes, NQO1 and HO-1, increased significantly, and HO-1 kept rising through 60 minutes, suggesting a lasting protective effect.

NQO1 elevated at 30 minutes — fast activation
HO-1 continued rising through 60 minutes — sustained defense
AO2 gives the skin a very strong defense after treatment.
Skin becomes more resilient to environmental stressors

FINDING 03

Your Skin Barrier Stays Completely Intact

Filaggrin, the key protein responsible for your skin’s barrier function and hydration, showed zero change across all time points. The treatment delivers oxygen without disrupting the skin’s protective layer.

Filaggrin levels unchanged at T0, T30, and T60
No disruption to the stratum corneum structure
Safe and non-disruptive — confirmed at the cellular level

WHAT THIS MEANS FOR YOUR SKIN

Targeted Oxygen Delivery. Stronger Skin. No Disruption.

Supports better oxygen availability at the pore and follicle level
Helps create a healthier environment for skin function
Maintains skin barrier integrity
Encourages a more balanced, resilient complexion

This research supports how oxygen nanobubble technology from AO2 SKIN works to improve overall skin health in a gentle, non-disruptive way.

STUDY ARCHITECTS

Dr. Zvi Yaniv, PhD

Chief Science Officer, AO2 SKIN

Nanotechnology pioneer with over 300 patents. The scientific architect behind AO2 SKIN’s oxygen nanobubble delivery technology.

Vivian Bucay, MD, FAAD

Chief Medical Officer, AO2 SKIN

Johns Hopkins and Baylor College of Medicine graduate. Considered one of the pre-eminent dermatologists in the United States.

Giuseppe Valacchi, PhD

David H. Murdock Distinguished Professor of Regenerative Medicine

World-leading expert in redox biology and skin science. Holds NC State’s highest faculty distinction.

MEET THE PRODUCTS

Ultra-pure skincare powered by gas nanobubbles. Minimal ingredients, maximum results for every skin type.

AO2 CLEAR

Oxygen nanobubbles for clarity

Impede proliferation of acne-causing bacteria
Reduce inflammation, redness, and congestion
Enhance tolerability of retinoids and active ingredients

Made with only distilled water and billions of oxygen nanobubbles.

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AO2 HYDRATE

Oxygen nanobubbles with glycerin for balance

Comforts dryness and restores moisture balance
Soothes and supports daily skin resilience
Lightweight feel with no residue

Made with only distilled water and billions of oxygen nanobubbles, and natural vegetable glycerin.

SHOP AO2 HYDRATE

NOT JUST clearer skin, but overall healthier looking skin

Both AO2 CLEAR and AO2 HYDRATE aren’t just better treatments, they are the foundation for healthier skin. Oxygen boosts overall wellness from the inside of your skin out, calming even minor inflammation for smoother tone and texture, and priming hydration so your skin can more fully absorb additional moisturizers. Whether you battle breakouts or not, AO2 SKIN is your path to the best skin of your life, guaranteed.

TELL ME MORE

5 reasons to try ao2 SKIN PRODUCTS now

1. POWER OF OXYGEN NANOBUBBLES
Combat inflammation effectively with concentrated oxygen.

2. HIGHEST STANDARD OF CLEAN
No fillers, no preservatives, just distilled water, oxygen, and patented science.

3. NO DRYNESS OR IRRITATION
Gentle on all skin types, without the side effects of traditional treatments.

4. VISIBLY HEALTHIER SKIN
AO2 isn’t just for clear skin; it’s the foundation for healthier, smoother skin.

5. 30 DAY CHALLENGE
Try AO2 for 30 consecutive days, using twice daily to see clearer & healthier skin. See money-back return policy.

TRY IT RISK FREE today

"I saw a reduction in my acne in only 2 weeks, with my skin becoming 100% acne-free in only 8 weeks. This product really gave me part of my life back after over a decade of nothing working. I tell literally everyone I know about this product!!!”

Paige

“I enjoy using AO2 considering that my skin got very dry from acne treatments, and I wanted something that is good for acne without harsh chemicals and over-drying.”

Alexandra

"AO2 Clear truly gave me my confidence back! After struggling with hormonal acne, eczema and the most sensitive skin, I was skeptical, but it exceeded all expectations. I will never not use this in my routine. I 1000% recommend!"

madeline

"I just started using AO2 a couple of weeks ago and I can already see a difference. My pores on and around my nose have gotten smaller and the tone of my face has really improved. It also feels really good during application and after I use it for the next couple of hours. My teenage kids also really like it and have noticed an improvement in their complexions. I look forward to using it each day."

— Sharon

"Total game changer. I’ve had sporadic issues with acne all my life… no more. Thanks to A02 now my skin is happy and healthy and clear, 100% of the time."

— Alex

"I love this product!!! I have been using it for 3 weeks now and, only after a few days, I noticed how clean and hydrated my skin felt. After one use my skin felt softer. I use it every morning and evening right after cleansing my face. I even started my husband on it and he also loves the way his skin feels after he puts it on. Go for it!!!!"

— Sonia

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