737-296-5085 info@ao2clear.com
AO2 CLEAR and AO2 HYDRATE pouches on black pedestals with a 10 mL AO2 MIST travel size in front
Our biggest sale of the year

off sitewide, plus a
free AO2 MIST.

Shop the saleCode GLOW25

NewAO2 MIST, our oxygen face and body mist, is here. Get the 10 mL travel size free with every kit, or shop the full size. Shop AO2 MIST →

Use code GLOW25 at checkout. Excludes sponges. Subscriptions automatically 26% off.

Our biggest sale of the year

off sitewide, plus a
free AO2 MIST.

Shop the sale
Code GLOW25

NEWAO2 MIST is here. Get the 10 mL travel size free with every kit.

NewAO2 MIST™ · for face + body

A breath of oxygen, anytime.

An ultra-fine face and body mist with billions of oxygen nanobubbles, for a quick reset after sun, travel and recycled air.

Shop AO2 MIST★★★★★ 5.0 reviews
100M+oxygen nanobubbles per mL
3simple ingredients, starting with distilled water
Face + bodyno rubbing, no rinsing
AO2 MIST 50 mL frosted glass bottle with a silver spray top
50 mL full size1.69 fl oz glass bottle
NEWAO2 MIST™ · face + body

A breath of oxygen, anytime.

An ultra-fine face and body mist with billions of oxygen nanobubbles, for a quick reset after sun, travel and recycled air.

Shop AO2 MIST★★★★★ 5.0 reviews
Woman in a bright bathroom holding an AO2 CLEAR pouch and a sponge
AO2 CLEAR® · for blemish-prone skin

Clear starts
with oxygen.

Billions of oxygen nanobubbles to calm inflammation, reduce congestion, and help keep pores clear without irritation.

Shop AO2 CLEAR25% off + free MIST

~88% reported improvement after one month.1

1 AO2 SKIN internal study. Individual results may vary.

AO2 CLEAR® · blemish-prone skin

Clear starts with oxygen.

Billions of oxygen nanobubbles to calm inflammation, reduce congestion, and help keep pores clear.

Shop AO2 CLEAR25% off + free MIST

~88% reported improvement after one month¹

¹ AO2 SKIN internal study. Individual results may vary.

AO2 HYDRATE pouch with water splashing over it on a purple background
AO2 HYDRATE™ · for dry, dehydrated or mature skin

Hydration,
simplified.

Oxygen nanobubbles with natural vegetable glycerin, for lasting moisture and balance.

Shop AO2 HYDRATE25% off + free MIST
3 ingredientsGlycerin for moistureAll skin types
AO2 HYDRATE™ · dry or mature skin

Hydration, simplified.

Oxygen nanobubbles with natural vegetable glycerin, for lasting moisture and balance.

Shop AO2 HYDRATE25% off + free MIST
3 ingredientsAll skin types

The AO2 SKIN collection

The future of skincare is here.

Patented oxygen nanobubbles, 1,000x smaller than a pore, deliver oxygen deep into the skin. Radically clean, simple formulas for every skin type, without harsh chemicals or long ingredient lists.

AO2 MIST 50 mL frosted glass bottleNew

For face + body, anytime

AO2 MIST™

A breath of oxygen, anytime.

  • Refreshes skin in seconds, anytime
  • Ultra-fine mist, no rubbing or rinsing
  • Made for your desk, gym bag and carry-on

Made with only distilled water, oxygen nanobubbles and phenoxyethanol.

Shop AO2 MIST →
AO2 CLEAR oxygen nanobubble skin therapy pouch

For blemish-prone skin

AO2 CLEAR®

Clear starts with oxygen.

  • Helps fight acne-causing bacteria
  • Reduces inflammation, redness and congestion
  • Makes retinoids and actives easier to tolerate

Made with only distilled water and billions of oxygen nanobubbles.

Shop AO2 CLEAR →
AO2 HYDRATE pouch

For dry or mature skin

AO2 HYDRATE™

Hydration, simplified.

  • Comforts dryness and restores moisture balance
  • Soothes and supports daily skin resilience
  • Lightweight feel with no residue

Made with only distilled water, billions of oxygen nanobubbles and natural vegetable glycerin.

Shop AO2 HYDRATE →

Swipe to see all three →

What Makes AO2 SKIN Different?

More Oxygen. Stronger Skin. No Disruption. Most skincare products rely on long ingredient lists, harsh actives, or complicated routines. AO2 SKIN™ takes a radically different approach. Using only distilled water and oxygen nanobubbles, AO2 SKIN helps increase oxygen availability within the skin while maintaining skin barrier integrity.

Independent research conducted with North Carolina State University demonstrated measurable changes in oxygen-related biomarkers following topical application of AO2 CLEAR® oxygen nanobubbles. Simple ingredients. Measurable science.

HOW TO USE AO2

What Makes AO2 SKIN Different?

More Oxygen. Stronger Skin. No Disruption. Most skincare products rely on long ingredient lists, harsh actives, or complicated routines.

AO2 SKIN™ takes a radically different approach. Using only distilled water and oxygen nanobubbles, AO2 SKIN helps increase oxygen availability within the skin while maintaining skin barrier integrity.

Independent research conducted with North Carolina State University demonstrated measurable changes in oxygen-related biomarkers following topical application of AO2 CLEAR® oxygen nanobubbles.

HOW TO USE AO2

What are Gas Nanobubbles?

Tiny Bubbles. Big Difference.
Nanobubbles are microscopic pockets of oxygen suspended in water. Unlike ordinary bubbles that quickly rise and disappear, nanobubbles remain stable in solution, allowing billions of oxygen nanobubbles to interact with the skin in ways traditional bubbles cannot.

THE SCIENCE

For The People Who’ve Tried Everything

★★★★★

“I tried every prescription, every cleanser, every $80 serum. AO2 CLEAR is the only thing that worked. My skin is completely clear for the first time since I was 14.”

Paige H.   ·   A decade of failed treatments   ·   Cleared in 8 weeks

VERIFIED

★★★★★

“AO2 Clear truly gave me my confidence back! After struggling with hormonal acne, eczema and the most sensitive skin, I was skeptical, but it exceeded all expectations. I will never not use this in my routine!”

Madeline M.   ·   Hormonal acne   ·   Cleared in 2 weeks

VERIFIED

★★★★★

“I enjoy using AO2 considering that my skin got very dry from acne treatments, and I wanted something that is good for acne without harsh chemicals and over-drying.”

Alexandra   ·   Cystic acne   ·   Progress after 3 weeks

VERIFIED

CLINICAL RESEARCH

Evidence of Oxygen Delivery Beneath the Skin Surface Without Disrupting the Skin Barrier

Researchers examined what happens inside human skin after topical application of AO2 SKIN’s oxygen nanobubbles, including oxygen penetration and skin barrier integrity

SEE FULL STUDY INCLUDING VIDEO AND DETAILED RESULTS 

THE STUDY

The First-of-Its-Kind Human Oxygen Nanobubble Enzyme Study

Conducted in collaboration with North Carolina State University and a board-certified dermatologist and nano-physicist, this study examined human skin biopsies collected before treatment and at 30- and 60-minute intervals following topical application of AO2 SKIN oxygen nanobubbles.

  • Human skin biopsies collected and analyzed directly
  • Quantitative immunofluorescence imaging
  • Independent academic research collaboration
  • Evaluation of oxygen-related biomarkers and skin barrier integrity

HOW OXYGEN WAS MEASURED

Your Skin Has It’s Own Oxygen Sensor

Your skin naturally has different oxygen levels at different depths. One important marker, called Hypoxia Inducible Factor-1 alpha (HIF-1α), helps scientists understand how much oxygen is available in the skin. When oxygen levels increase, this marker goes down.
 
AO2 CLEAR® oxygen nanobubbles were applied to the skin, and biopsies were collected before treatment and again at 30 and 60 minutes following application.

FINDING 01

Oxygen Actually Reaches The Epidermis and Dermis

The study measured HIF-1α, a biomarker that rises when skin is low on oxygen and drops when oxygen improves. After applying AO2 SKIN, HIF-1α decreased significantly; direct biochemical proof that oxygen was delivered into the tissue.
 
  • HIF-1α is a validated scientific measure of tissue oxygenation
  • Results were significant at both 30 and 60 minutes
  • This is the body’s own oxygen sensor confirming the positive penetration and effects of AO2

FINDING 02

Your Skin’s Own Defenses Get Stronger

Beyond oxygenation, the study found that AO2 SKIN activates the skin’s natural antioxidant defense system. Two key protective enzymes, NQO1 and HO-1, increased significantly, and HO-1 kept rising through 60 minutes, suggesting a lasting protective effect.
 
  • NQO1 elevated at 30 minutes — fast activation
  • HO-1 continued rising through 60 minutes — sustained defense
  • AO2 gives the skin a very strong defense after treatment.
  • Skin becomes more resilient to environmental stressors

FINDING 03

Your Skin Barrier Stays Completely Intact

Filaggrin, the key protein responsible for your skin’s barrier function and hydration, showed zero change across all time points. The treatment delivers oxygen without disrupting the skin’s protective layer.
 
  • Filaggrin levels unchanged at T0, T30, and T60
  • No disruption to the stratum corneum structure
  • Safe and non-disruptive — confirmed at the cellular level

WHAT THIS MEANS FOR YOUR SKIN

Targeted Oxygen Delivery. Stronger Skin. No Disruption.

  • Supports better oxygen availability at the pore and follicle level
  • Helps create a healthier environment for skin function
  • Maintains skin barrier integrity
  • Encourages a more balanced, resilient complexion
This research supports how oxygen nanobubble technology from AO2 SKIN works to improve overall skin health in a gentle, non-disruptive way.

STUDY ARCHITECTS

Dr. Zvi Yaniv, PhD

Dr. Zvi Yaniv, PhD

Chief Science Officer, AO2 SKIN

Nanotechnology pioneer with over 300 patents. The scientific architect behind AO2 SKIN’s oxygen nanobubble delivery technology.

Vivian Bucay, MD, FAAD

Vivian Bucay, MD, FAAD

Chief Medical Officer, AO2 SKIN

Johns Hopkins and Baylor College of Medicine graduate. Considered one of the pre-eminent dermatologists in the United States.

Giuseppe Valacchi, PhD

Giuseppe Valacchi, PhD

David H. Murdock Distinguished Professor of Regenerative Medicine

World-leading expert in redox biology and skin science. Holds NC State’s highest faculty distinction.

Not Just Clearer Skin, But Overall Healthier Skin

AO2 CLEAR, AO2 HYDRATE and AO2 MIST aren’t just better treatments, they are the foundation for healthier skin. Oxygen boosts overall wellness from the inside of your skin out, calming even minor inflammation for smoother tone and texture, and priming hydration so your skin can more fully absorb additional moisturizers. Whether you battle breakouts or not, AO2 SKIN is your path to the best skin of your life, guaranteed.

TELL ME MORE

5 Reasons to Try AO2 SKIN Products Now

1. POWER OF OXYGEN NANOBUBBLES
Combat inflammation effectively with concentrated oxygen.

2. HIGHEST STANDARD OF CLEAN
No fillers, no preservatives, just distilled water, oxygen, and patented science.

3. NO DRYNESS OR IRRITATION
Gentle on all skin types, without the side effects of traditional treatments.

4. VISIBLY HEALTHIER SKIN
AO2 isn’t just for clear skin; it’s the foundation for healthier, smoother skin.

5. 30 DAY CHALLENGE
Try AO2 for 30 consecutive days, using twice daily to see clearer & healthier skin. See money-back return policy.

    TRY IT RISK FREE today

    "I just started using AO2 a couple of weeks ago and I can already see a difference. My pores on and around my nose have gotten smaller and the tone of my face has really improved. It also feels really good during application and after I use it for the next couple of hours. My teenage kids also really like it and have noticed an improvement in their complexions. I look forward to using it each day."

    — Sharon

    "Total game changer. I’ve had sporadic issues with acne all my life… no more. Thanks to A02 now my skin is happy and healthy and clear, 100% of the time."

    — Alex

    "I love this product!!! I have been using it for 3 weeks now and, only after a few days, I noticed how clean and hydrated my skin felt. After one use my skin felt softer. I use it every morning and evening right after cleansing my face. I even started my husband on it and he also loves the way his skin feels after he puts it on. Go for it!!!!"

    — Sonia

    Subscribe To Our Newsletter and Follow Us On Instagram @ao2_clear

     

    Subscribe to our newsletter for exclusive skincare tips, product updates, and special offers delivered directly to your inbox. Join our community of radiant skin enthusiasts and embark on a journey to healthier, clearer skin together.