PRO PARTNER PROGRAM

Lead with Science that Delivers Results.

Exclusive wholesale pricing available!

Interested in Becoming a Wholesale Pro Partner?

Our AO2 SKIN Pro Partner Program is designed to support your practice with exclusive wholesale pricing, upgraded professional kits, and powerful tools to help you grow.

As a Pro Partner, you’ll receive:
• Exclusive wholesale pricing on our Pro Kits
• Access to our Pro Partner Ambassador Program to earn commission on patient orders placed online
• A private Pro Partner Hub with training, marketing assets and more
• Direct access to our Chief Medical Officer and Head of Sales for personalized support

Want to learn more? Email us at wholesale@ao2clear.com or fill out the form below and we’ll follow up with details and get you started.

Interested in Becoming a Pro Partner?

Our AO2 CLEAR Pro Partner Program is designed to support your practice with exclusive wholesale pricing, upgraded professional kits, and powerful tools to help you grow.

As a Pro Partner, you’ll receive:
• Exclusive wholesale pricing on our Pro Kits
• Access to our Referral Program to earn commission on patient orders placed online
• A private Pro Partner Hub with training, marketing assets and more
• Direct access to our Chief Medical Officer and VP of Business Development for personalized support

Want to learn more? Email us at wholesale@ao2clear.com or fill out the form below—we’ll follow up with details and get you started.

A NOTE FROM VALERIE HANFT, MD

 

My name is Valerie Hanft, MD, and I am a board-certified dermatologist and Advisory Board Member for O2 Partners. Whether you’ve heard about AO2 Clear before or this is your first introduction, I’m excited to share a radically new approach to achieving clearer, healthier skin with you and your practice.

Our product, AO2 Clear®, is a novel formulation containing two simple ingredients – distilled water and oxygen. Nothing else. We use a patented nanobubble technology to deliver the highest concentration of oxygen of any skincare product on the market.

As you know, the bacteria that cause acne (Cutibacteria acnes) thrive in an environment devoid of oxygen. Because AO2 floods the pores with oxygen, this treatment is antibacterial without any risks of traditional antibiotics. We have found that it is effective in all skin types, has no potential for adverse reactions (irritation, redness, or dryness), and is safe for all patients, including those who are pregnant, nursing, or trying to conceive.

 

Since our original product launch, we noticed that our customers have reported many benefits beyond clearing blemishes. Users report their skin feels smoother and more hydrated. Those who have had procedures like Fraxel, chemical peels, and microneedling report their skin heals faster. Users have also reported better tolerance of drying agents such as topical retinoids and oral Accutane. Read more in our study results below.

AO2 Clear is simple to use—it is applied twice daily with supplied sponges. There is no need to change any existing skincare regimen.

Dr. Valerie Hanft

Valerie Hanft, MD

A NOTE FROM

Valerie Hanft, MD

Dr. Valerie Hanft

Valerie Hanft, MD

My name is Valerie Hanft, MD, and I am a board-certified dermatologist and Advisory Board Member for O2 Partners. Whether you’ve heard about AO2 Clear before or this is your first introduction, I’m excited to share a radically new approach to achieving clearer, healthier skin with you and your practice.

Our product, AO2 Clear®, is a novel formulation containing two simple ingredients – distilled water and oxygen. Nothing else. We use a patented nanobubble technology to deliver the highest concentration of oxygen of any skincare product on the market.

As you know, the bacteria that cause acne (Cutibacteria acnes) thrive in an environment devoid of oxygen. Because AO2 floods the pores with oxygen, this treatment is antibacterial without any risks of traditional antibiotics. We have found that it is effective in all skin types, has no potential for adverse reactions (irritation, redness, or dryness), and is safe for all patients, including those who are pregnant, nursing, or trying to conceive.

Since our original product launch, we noticed that our customers have reported many benefits beyond clearing blemishes. Users report their skin feels smoother and more hydrated. Those who have had procedures like Fraxel, chemical peels, and microneedling report their skin heals faster. Users have also reported better tolerance of drying agents such as topical retinoids and oral Accutane. See more in our study results below.

AO2 Clear is simple to use—it is applied twice daily with supplied sponges. There is no need to change any existing skincare regimen.

CLINICAL RESEARCH

Evidence of Oxygen Delivery Beneath the Skin Surface Without Disrupting the Skin Barrier

Researchers examined what happens inside human skin after topical application of AO2 SKIN's oxygen nanobubbles, including oxygen penetration and skin barrier integrity

SEE FULL STUDY INCLUDING VIDEO AND DETAILED RESULTS 

THE STUDY

The First-of-Its-Kind Human Oxygen Nanobubble Enzyme Study

Conducted in collaboration with North Carolina State University and a board-certified dermatologist and nano-physicist, this study examined human skin biopsies collected before treatment and at 30- and 60-minute intervals following topical application of AO2 SKIN oxygen nanobubbles.

  • Human skin biopsies collected and analyzed directly
  • Quantitative immunofluorescence imaging
  • Independent academic research collaboration
  • Evaluation of oxygen-related biomarkers and skin barrier integrity

HOW OXYGEN WAS MEASURED

Your Skin Has It's Own Oxygen Sensor

Your skin naturally has different oxygen levels at different depths. One important marker, called Hypoxia Inducible Factor-1 alpha (HIF-1α), helps scientists understand how much oxygen is available in the skin. When oxygen levels increase, this marker goes down.
 
AO2 CLEAR® oxygen nanobubbles were applied to the skin, and biopsies were collected before treatment and again at 30 and 60 minutes following application.

FINDING 01

Oxygen Actually Reaches The Epidermis and Dermis

The study measured HIF-1α, a biomarker that rises when skin is low on oxygen and drops when oxygen improves. After applying AO2 SKIN, HIF-1α decreased significantly; direct biochemical proof that oxygen was delivered into the tissue.
 
  • HIF-1α is a validated scientific measure of tissue oxygenation
  • Results were significant at both 30 and 60 minutes
  • This is the body's own oxygen sensor confirming the positive penetration and effects of AO2

FINDING 02

Your Skin's Own Defenses Get Stronger

Beyond oxygenation, the study found that AO2 SKIN activates the skin's natural antioxidant defense system. Two key protective enzymes, NQO1 and HO-1, increased significantly, and HO-1 kept rising through 60 minutes, suggesting a lasting protective effect.
 
  • NQO1 elevated at 30 minutes — fast activation
  • HO-1 continued rising through 60 minutes — sustained defense
  • AO2 gives the skin a very strong defense after treatment.
  • Skin becomes more resilient to environmental stressors

FINDING 03

Your Skin Barrier Stays Completely Intact

Filaggrin, the key protein responsible for your skin's barrier function and hydration, showed zero change across all time points. The treatment delivers oxygen without disrupting the skin's protective layer.
 
  • Filaggrin levels unchanged at T0, T30, and T60
  • No disruption to the stratum corneum structure
  • Safe and non-disruptive — confirmed at the cellular level

WHAT THIS MEANS FOR YOUR SKIN

Targeted Oxygen Delivery. Stronger Skin. No Disruption.

  • Supports better oxygen availability at the pore and follicle level
  • Helps create a healthier environment for skin function
  • Maintains skin barrier integrity
  • Encourages a more balanced, resilient complexion
This research supports how oxygen nanobubble technology from AO2 SKIN works to improve overall skin health in a gentle, non-disruptive way.

STUDY ARCHITECTS

Dr. Zvi Yaniv, PhD

Dr. Zvi Yaniv, PhD

Chief Science Officer, AO2 SKIN

Nanotechnology pioneer with over 300 patents. The scientific architect behind AO2 SKIN's oxygen nanobubble delivery technology.

Vivian Bucay, MD, FAAD

Vivian Bucay, MD, FAAD

Chief Medical Officer, AO2 SKIN

Johns Hopkins and Baylor College of Medicine graduate. Considered one of the pre-eminent dermatologists in the United States.

Giuseppe Valacchi, PhD

Giuseppe Valacchi, PhD

David H. Murdock Distinguished Professor of Regenerative Medicine

World-leading expert in redox biology and skin science. Holds NC State's highest faculty distinction.

Clinical Patitent Study Results

AO2 CLEAR conducted a prospective patient study involving 14 clinicians. They distributed a one month supply of AO2 CLEAR to be used twice daily for acne, dermatitis, post-procedure healing, hydration, or improvement of tolerability of other products. A total of 66 responses were received.

The responses were overwhelmingly positive not only for efficacy for the varied indications, but also for convenience and enjoyment of the overall product experience.

 

Primary Uses Among Patients

The majority of patients (66%) were using AO2 Clear for treatment of acne followed by post-procedure healing (16%), improving tolerability of other products (12%), and hydration/ treatment of dermatitis (6%).

Patient Improvement

After one month of use, 88% reported improvement with 35% of this group describing the result as dramatic improvement.

Likelihood of Recommending

Similarly, the majority of patients (77%) reported they would recommend the product to a friend.

Patient Enjoyment

These results were reflected in a 86% overall satisfaction rate with almost half of all patients reporting they loved using AO2 Clear.

Hear what professionals are saying

Watch these videos from leading dermatologists, estheticians, and medical professionals to learn why they’ve made AO2 Clear a key part of their practice.

The Power of Oxygen

Acne Solutions

Benefits Beyond Acne

Post-Procedure and Clinical Benefits

Incorporating AO2

Retnoid Tolerability

Pregnancy-Safe

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