AO2 Clear Pro Pack
Exclusive for skincare professionals. Our Wholesale Program makes it easy to integrate AO2 Clear into your practice, with exclusive professional pricing and strong margins for your business.
I’ve been using this product for only a week but I am already very impressed by it! I have hormonal acne which is not easy to control. My pores look much cleaner and my skin feels a lot softer. I love the healthy look and how easy it feels to apply moisturizer afterwards. I will update my review after trying it for longer but I am very pleased with the results so far.
— Cristiane Nunes dos Santos, MD.
$719.98
For Returning Wholesale Customers
You’re in the right place—use your exclusive wholesale code at checkout to access professional pricing and place your next order.
For New Wholesale Customers
Interested in becoming a partner? Email us at wholesale@ao2clear.com or fill out the form at the bottom of this page to receive your exclusive pricing code and start offering AO2 Clear to your clients.
A LETTER FROM AO2’S
CHIEF MEDICAL OFFICER

Valerie Hanft, MD
My name is Valerie Hanft, MD, and I am a board-certified dermatologist and the Chief Medical Officer for O2 Partners. Whether you’ve heard about AO2 Clear before or this is your first introduction, I’m excited to share a radically new approach to achieving clearer, healthier skin with you and your practice.
Our product, AO2 Clear®, is a novel formulation containing two simple ingredients – distilled water and oxygen. Nothing else. We use a patented nanobubble technology to deliver the highest concentration of oxygen of any skincare product on the market.
As you know, the bacteria that cause acne (Cutibacteria acnes) thrive in an environment devoid of oxygen. Because AO2 floods the pores with oxygen, this treatment is antibacterial without any risks of traditional antibiotics. We have found that it is effective in all skin types, has no potential for adverse reactions (irritation, redness, or dryness), and is safe for all patients, including those who are pregnant, nursing, or trying to conceive.
Since our original product launch, we noticed that our customers have reported many benefits beyond clearing blemishes. Users report their skin feels smoother and more hydrated. Those who have had procedures like Fraxel, chemical peels, and microneedling report their skin heals faster. Users have also reported better tolerance of drying agents such as topical retinoids and oral Accutane. See more in our study results below.
AO2 Clear is simple to use—it is applied twice daily with supplied sponges. There is no need to change any existing skincare regimen.
AO2 Chief Medical Officer
My name is Valerie Hanft, MD, and I am a board-certified dermatologist and the Chief Medical Officer for O2 Partners. Whether you’ve heard about AO2 Clear before or this is your first introduction, I’m excited to share a radically new approach to achieving clearer, healthier skin with you and your practice.
Our product, AO2 Clear®, is a novel formulation containing two simple ingredients – distilled water and oxygen. Nothing else. We use a patented nanobubble technology to deliver the highest concentration of oxygen of any skincare product on the market.
As you know, the bacteria that cause acne (Cutibacteria acnes) thrive in an environment devoid of oxygen. Because AO2 floods the pores with oxygen, this treatment is antibacterial without any risks of traditional antibiotics. We have found that it is effective in all skin types, has no potential for adverse reactions (irritation, redness, or dryness), and is safe for all patients, including those who are pregnant, nursing, or trying to conceive.
Since our original product launch, we noticed that our customers have reported many benefits beyond clearing blemishes. Users report their skin feels smoother and more hydrated. Those who have had procedures like Fraxel, chemical peels, and microneedling report their skin heals faster. Users have also reported better tolerance of drying agents such as topical retinoids and oral Accutane. Read more in our study results below.
AO2 Clear is simple to use—it is applied twice daily with supplied sponges. There is no need to change any existing skincare regimen.

Valerie Hanft, MD
Hear what Your peers are saying
Watch these videos from leading dermatologists, estheticians, and medical professionals to learn why they’ve made AO2 Clear a key part of their practice
The Power of Oxygen
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Acne Solutions
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Benefits Beyond Acne
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Post-Procedure and Clinical Benefits
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Incorporating AO2
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Retnoid Tolerability
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Pregnancy-Safe
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Clinical Study Results
AO2 Clear conducted a prospective patient study involving 14 clinicians. They distributed a one month supply of AO2 Clear to be used twice daily for acne, dermatitis, post-procedure healing, hydration, or improvement of tolerability of other products. A total of 66 responses were received.
The responses were overwhelmingly positive not only for efficacy for the varied indications, but also for convenience and enjoyment of the overall product experience.

Primary Uses Among Patients
The majority of patients (66%) were using AO2 Clear for treatment of acne followed by post-procedure healing (16%), improving tolerability of other products (12%), and hydration/ treatment of dermatitis (6%).

Patient Improvement
After one month of use, 88% reported improvement with 35% of this group describing the result as dramatic improvement.

Likelihood of Recommending
Similarly, the majority of patients (77%) reported they would recommend the product to a friend.

Patient Enjoyment
These results were reflected in a 86% overall satisfaction rate with almost half of all patients reporting they loved using AO2 Clear.
Acne relief portraits

– Perla

– Steve

– Jenny

"Hands down one of the best acne/compromised skin products that I’ve used in a very long time. Works immediately to tackle the problem."
Eva Simmons – O’Brien., MD

"Hands down one of the best acne/compromised skin products that I’ve used in a very long time. Works immediately to tackle the problem."
– Eva Simmons – O’Brien., MD
Dr. Hanft’s advice: “Just add AO2 Clear to your existing routine.”
Whether you wash and go or have a multistep skin care regimen, all you need to do is apply AO2 Clear after cleansing and allow to dry. Just like our ingredient list, AO2 Clear is simple, clean, and ideal for all skin types.
Skin types that can benefit from AO2 CLEAR
-
- Dull complexion
- Skin irritated by other topicals (retinoids, hydroxy acids, etc)
- Skin healing after a procedure such as laser or a peel
Hands down one of the best acne/compromised skin products that I’ve used in a very long time. Works immediately to tackle the problem.